Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer

Graphical abstract Abstract The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes myometrial contraction labour at term or preterm appears to share some common mechanisms with occurrence, growth, invasion and metastasis cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases pivotal complex tissue modulation includes degradation, exchange ECM components, which contribute homeostasis under normal physiological conditions such as during pregnancy puerperium. However, in cancer uterine cervix, this extensive network is altered leading disrupted cell–cell cell–basement membrane adhesion, abnormal neovascularization disrupt homeostasis. Cervical puerperium could be a albeit benign neoplasm. In review, we examined pathophysiologic differences similarities role MMPs Lay summary During childbirth, barrel-shaped lower portion womb connects vagina, gradually softens, shortens opens allow birth baby. This process requires structural biochemical changes stimulated by enzymes known metalloproteinases. Interestingly, these also affect framework cancer, although cancers usually occur after infection human papillomavirus. review intended identify explain between chemical childbirth seen cancer.